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Max Joint is a combination of Glucosamine Sulphate, Chondroitin
Sulphate and MSM, providing a good source of glycosaminoglycans
and sulphur which are important for the growth and maintenance
of healthy cartilage and joints. It also contains white willow
which is an anti-inflammatory and analgesic herb.Max Joint is
beneficial for joint problems such as osteoarthritis, sprains
and strains, knee pains or back pain and etc.
Glucosamine Sulphate seems to be the most beneficial form of
glucosamine as it is the only form shown in clinical trials to
be effective for osteoarthritis. Glucosamine is an important
building block needed by the body to manufacture
glycosaminoglycans, key structural components of cartilage. It
helps to stimulate the cells that produce these
glycosaminoglycans and normalise cartilage metabolism by
inhibiting their breakdown and exerting anti-inflammatory
effects. Glucosamine sulphate is used to help the body to repair
damaged or eroded cartilage. It has been used to help with
osteoarthritis, and acts to improve connective tissue structure
in the intestine.
The efficacy and tolerance of glucosamine sulphate were
investigated in 30 patients with osteoarthritis. The patients
were divided into two groups where one group received
glucosamine and the other one received placebo for three weeks.
Efficacy was tested by semi-quantitative scoring of pain at rest
and during active and passive movements, as well as the
limitation of articular function, before and after 7 and 21 days
of treatment. Patients were positively questioned daily for
possible intolerance symptoms.
During both initial parenteral treatments, each symptom
significantly improved, but to a faster and greater extent in
the group treated with glucosamine. A further improvement was
recorded in the patients treated with glucosamine during the
maintenance period, whereas in the placebo group, the symptom
scores increased almost to the pre-treatment level. Clinical and
biological tolerances were excellent with both treatments. It is
suggested that parental and oral treatment with glucosamine
sulphate should be considered as basic therapy for the
management of primary or secondary degenerative osteoarthritis
disorders.
Chondroitin Sulphate is found in the cartilage, bone and
connective tissues of most mammals. It is rich in sulphur and
consists of repeating chains of molecules called
glycosaminoglycans. Numerous clinical studies have demonstrated
the efficacy of chondroitin sulphate in osteoarthritis involving
the hip, knee and finger joints.
In
France, the efficacy and tolerability of chondroitin sulphate
were studied. A total of 127 patients with mono or bilateral
knee osteoarthritis were supplemented with chondroitin sulphate
or placebo for three month period.
A
significant reduction of clinical symptoms was observed in the
chondroitin sulphate group, while only a slight reduction was
observed in the placebo group. The supplementation of
chondroitin sulphate was found to be very well tolerated. The
results indicate that chondroitin sulphate favours the
improvement of the subjective symptoms, improving the joint
mobility.
Another controlled, randomized, double-blind study versus
placebo was conducted in 104 patients with femorotibial
osteoarthritis. After one year of consuming, the functional
impairment was reduced by approximately 50% and a significant
improvement over placebo for all clinical criteria. Chondroitin
was well tolerated by the patients and it acts as structural
modulators.
Methyl Sulfonyl Methane (MSM) is a naturally occurring, organic,
sulphurcontaining compound. It is found throughout nature and
has been detected in the blood and urine of humans.
A
double blind study of its use in degenerative arthritis has been
carried out by Lawrence RM. Sixteen patients suffering from
degenerative arthritis were evaluated on the effect of using MSM
to control their pain. Ten randomly chosen patients were given
MSM daily and six received placebo capsules for six weeks. The
result indicated 80% improvement in pain on average among the
patients receiving MSM, while a minimal improvement in the
placebo group.
White willow has been used by traditional herbalists for fever,
headache, pain and rheumatic complaints. In the late 19th
century, the constituent salicylic acid was isolated from
white willow bark and went on to become the model for the
development of aspirin. White willow is one of the natural
sources of aspirin and it has anti-inflammatory and analgesic
properties.
A
German trial assessed the clinical efficacy and tolerability of
willow bark extract in patients with osteoarthritis. A total of
78 patients participated the trial with half receiving willow
and the other half receiving placebo for two weeks.There was a
statistically significant difference in the observed pain
dimension and pain score between the supplementation group and
the placebo group. The results showed superiority of the willow
bark extract over the placebo. It was concluded that the willow
bark extract showed a moderate analgesic effect in
osteoarthritis and appeared to be well tolerated.
A
similar study was carried out in Israel to evaluate the
effectiveness of willow bark extract for low back pain. A total
of 191 patients completed the four weeks study. A number of
patients reported pain-free response. It was found that willow
bark extract was effective in reducing the exacerbations of low
back pain. Max Joint has been designed with these potent
ingredients that have been clinical studied for the joint
functions. Therefore, it is a beneficial supplement for
individuals with joint problems.
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